GATTACA vs d5SICS and dMMO2

Once upon a time we had four nucleotides (A,G,C,T) pairing to form the double helix of DNA. Today two artificial nucleotides, d5SICS and dMMO2, able to pair and to be included in DNA structures, have been synthesized. Going from 4 to 6 nucleotides is a big leap for the genetic code and especially for amino acids variability. If now we can have 4^3 possible different amino acids (as each one could be determined during protein synthesis by codes of tree nucleotides), in the future we could have 6^3 different combinations available. Known amino acids nowadays are 20-23. How could artificial life made out of possible 216 amino acids (just hypothesis for a non degenerated code) look like?